Indirect induction of lymphomas in irradiated mice. I. Tumor incidence and morphology in mice bearing nonirradiated thymic grafts.
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منابع مشابه
Effect of hypothyroidism and thyroid grafts on lymphoid tumor development in irradiated C57BL mice.
Endocrine factors condition susceptibility of some strains of mice to the induction of lymphoid tumors by various carcinogenic agents (reviews by Kaplan et a/. [14], Gardner eta/. [6]). In previous work adrenalectomy or orchiectomy augmented, whereas cortisone, hydrocortisone, or testosterone inhibited, the leukemogenic process (9, 10, 13). Hypophysectomy failed to influence the incidence of ra...
متن کاملEffect of Hypothyroidism and Thyroid Grafts on Lymphoid Tumor Development in Irradiated C57BL Mice*
Endocrine factors condition susceptibility of some strains of mice to the induction of lymphoid tumors by various carcinogenic agents (reviews by Kaplan et a/. [14], Gardner eta/. [6]). In previous work adrenalectomy or orchiectomy augmented, whereas cortisone, hydrocortisone, or testosterone inhibited, the leukemogenic process (9, 10, 13). Hypophysectomy failed to influence the incidence of ra...
متن کاملReconfirmation of indirect induction of radiogenic lymphomas using thymectomized, irradiated B10 mice grafted with neonatal thymuses from Thy 1 congenic donors.
An experiment was conducted to reexamine earlier observations that lymphomas could develop from lymphocytes present in nonirradiated thymuses grafted into thymectomized, fractionally (170 R, 4 doses) irradiated mice by using B10. Thy 1 congenic donor-host combinations. The results indicated that: (a) 37 of 91 thymectomized, fractionally irradiated B10. Thy 1.2 mice which were grafted s.c. with ...
متن کاملIndirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen
The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b) the induction of T cell lymphomas of host origin in mice infused with bone marrow from irradiated, Thy-l-congenic donors. The latter procedure a...
متن کاملIndirect induction of lymphomas in irradiated mice. III. Role of the thymic graft.
that lymphoid tumors arise in nonirradiated thy mic grafts implanted into previously thymecto mized, irradiated CS7BL mice. This phenomenon provides a unique experimental model for the study of those components of the tumor-inducing mechanism which are intrinsic properties of the graft, as distinguished from those which are mcdi ated through its environment, the host. Irradia tion of the host i...
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ورودعنوان ژورنال:
- Cancer research
دوره 16 5 شماره
صفحات -
تاریخ انتشار 1956